Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities

Yuan-Nan Yuan; Jin-Qiang Li; Hong-Bin Fang; Shao-Jun Xing; Yong-Ming Yan; Yong-Xian Cheng

doi:10.3762/bjoc.19.59

Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities

Beilstein J Org Chem. 2023 Jun 7:19:789-799. doi: 10.3762/bjoc.19.59. eCollection 2023.

Authors

Yuan-Nan Yuan^{1

2}, Jin-Qiang Li^{2

3}, Hong-Bin Fang², Shao-Jun Xing³, Yong-Ming Yan², Yong-Xian Cheng^{1

2}

Affiliations

¹ School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
² Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, PR China.
³ Department of Pathogen Biology, Health Science Center, Shenzhen University, Shenzhen 518060, PR China.

Abstract

Six new compounds, including a tetralone 1, two xanthones 2 and 3, a flavan derivative 4, and two nor-diterpenoids 7 and 8, accompanied by two known flavan derivatives 5 and 6 and a known olefine acid (9) were isolated from whole bodies of Kronopolites svenhedini (Verhoeff). The structures of the new compounds were determined by 1D and 2D nuclear magnetic resonance (NMR) and other spectroscopic methods, as well as computational methods. Selected compounds were evaluated for their biological properties against a mouse pancreatic cancer cell line and inhibitory effects on iNOS and COX-2 in RAW264.7 cells.

Keywords: Kronopolites svenhedini (Verhoeff); arthropod; iNOS; non-peptide small molecules.

Grants and funding

This study was supported financially by the Shenzhen Science and Technology Program (No. KQTD20210811090219022), the Shenzhen Fundamental Research Program (No. JCYJ20200109114225087, JCYJ20210324120213038), and the National Science Fund for Distinguished Young Scholars (No. 81525026).