Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging

Simon Burg; Ralf Smeets; Martin Gosau; Katja Failing; Audrey Laure Céline Grust

doi:10.3389/fonc.2023.1177237

Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging

Front Oncol. 2023 Jun 6:13:1177237. doi: 10.3389/fonc.2023.1177237. eCollection 2023.

Authors

Simon Burg¹, Ralf Smeets^{1

2}, Martin Gosau¹, Katja Failing³, Audrey Laure Céline Grust^{1

2}

Affiliations

¹ Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
² Department of Oral and Maxillofacial Surgery, Division of "Regenerative Orofacial Medicine", University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
³ Precura Center, Darmstadt, Germany.

Abstract

We present the case of a 53-year-old woman who was diagnosed with early-stage lung cancer by targeted cancer screening consisting of an immunological biopsy-based blood test followed by radiological imaging. The PanTum Detect blood test detects the biomarkers Apo10/DNaseX and Transketolase-like 1 (TKTL1) in circulating macrophage-like cells from peripheral blood samples to identify asymptomatic individuals with a high risk for malignancy. The elevated blood test values initiated an ¹⁸F-FDG PET/CT visualization for further clarification. In this case, imaging indicated a lung carcinoma in the right upper lobe. A biopsy confirmed the presence of a lung carcinoma, which was removed surgically. Histologic examination revealed a typical I A2 carcinoid, which was completely removed, making further therapy obsolete.

Keywords: Apo10/DNaseX; FDG-PET/CT; TKTL1; blood test; early cancer screening; immunological biopsy.

Publication types

Case Reports