Pathogenic role of S100 proteins in psoriasis

Huifang Liang; Junqin Li; Kaiming Zhang

doi:10.3389/fimmu.2023.1191645

Pathogenic role of S100 proteins in psoriasis

Front Immunol. 2023 Jun 6:14:1191645. doi: 10.3389/fimmu.2023.1191645. eCollection 2023.

Authors

Huifang Liang^{1

2}, Junqin Li^{1

2}, Kaiming Zhang^{1

2}

Affiliations

¹ ShanXi Key Laboratory of Stem Cells for Immunological Dermatosis, Institute of Dermatology, Taiyuan City Center Hospital, Taiyuan, China.
² State Key Breeding Laboratory of Stem Cells for Immunological Dermatosis, Institute of Dermatology, Taiyuan City Center Hospital, Taiyuan, China.

Abstract

Psoriasis is a chronic inflammatory skin disease. The histopathological features of psoriasis include excessive proliferation of keratinocytes and infiltration of immune cells. The S100 proteins are a group of EF-hand Ca²⁺-binding proteins, including S100A2, -A7, -A8/A9, -A12, -A15, which expression levels are markedly upregulated in psoriatic skin. These proteins exert numerous functions such as serving as intracellular Ca²⁺ sensors, transduction of Ca²⁺ signaling, response to extracellular stimuli, energy metabolism, and regulating cell proliferation and apoptosis. Evidence shows a crucial role of S100 proteins in the development and progress of inflammatory diseases, including psoriasis. S100 proteins can possibly be used as potential therapeutic target and diagnostic biomarkers. This review focuses on the pathogenic role of S100 proteins in psoriasis.

Keywords: S100 proteins; inflammation; interaction; psoriasis; signaling pathways.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Keratinocytes / metabolism
Psoriasis*
S100 Calcium Binding Protein A7 / metabolism
S100 Proteins* / metabolism
Skin / pathology

Substances

S100 Proteins
S100 Calcium Binding Protein A7

Grants and funding

This work was supported by the National Natural Science Foundation of China (No. 81773336); the Shanxi Provincial Natural Science Foundation of China (No. 202203021211008) and the Shanxi Provincial Natural Science Foundation of China (No. 202103021224002).