Highly Efficient Oxindole-Based Molecular Photoswitches

Chemistry. 2023 Oct 2;29(55):e202301634. doi: 10.1002/chem.202301634. Epub 2023 Sep 1.

Abstract

3-Benzylidene-indoline-2-ones play a prominent role in the pharmaceutical industry due to the diverse biomedical applications of oxindole heterocycles. Despite the extensive reports on their biological properties, these compounds have hardly been studied for their photochemical activity. Here, we present 3-benzylidene-indoline-2-ones as a promising class of photoswitches with high yields, robust photochemical switching with quantum yields reaching up to 50 % and potential for biological applications.

Keywords: molecular photoswitches; oxindole; photochemistry; quantum yields; visible light.