Pelliolatifolias A-D, Four Undescribed Compounds from Pellionia latifolia Boerl. and Their Nitric Oxide Production Inhibitory Activity

Abstract

Four undescribed compounds (1-4) named pelliolatifolias A-D together with seven known compounds trans-clovamide (5), N-trans-caffeoyl-4-hydroxyphenylalanine methyl ester (6), N-trans-caffeoyl-3,4-dihydroxyphenylalanine methyl ester (7), luteolin 4'-O-β-D-glucopyrannoside (8), cis-syringin (9), trans-syringin (10), and citroside A (11) have been isolated from the methanol extract of the Pellionia latifolia leaves. Their chemical structures were elucidated based on extensive analyses of HR-ESI-MS, 1D and 2D NMR, and CD spectra. Compounds 1-7, 9 and 10 showed moderate inhibition of NO production in LPS-activated RAW264.7 cells with their IC₅₀ values ranging from 39.27 to 75.42 μM, compared to that of the positive control compound, dexamethasone, IC₅₀ value of 14.20 μM.

Keywords: Pellionia latifolia; pelliolatifolia A; pelliolatifolia B; pelliolatifolia C; pelliolatifolia D.