Undescribed steroidal alkaloids from the bulbs of Fritillaria sinica

Jia-Yuan Li; Shi-Fei Wu; Ya-Ling An; Chang-Liang Yao; Shuai Yao; Yong Huang; Wen-Long Wei; Jian-Qing Zhang; Qi-Rui Bi; Hua Qu; De-An Guo

doi:10.1016/j.phytochem.2023.113768

Undescribed steroidal alkaloids from the bulbs of Fritillaria sinica

Phytochemistry. 2023 Sep:213:113768. doi: 10.1016/j.phytochem.2023.113768. Epub 2023 Jun 19.

Authors

Affiliations

¹ National Engineering Research Center of TCM Standardization Technology, Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
² National Engineering Research Center of TCM Standardization Technology, Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
³ National Engineering Research Center of TCM Standardization Technology, Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: daguo@simm.ac.cn.

PMID: 37343737
DOI: 10.1016/j.phytochem.2023.113768

Abstract

Eight undescribed steroidal alkaloid derivatives, including three cevanine-type isosteroidal alkaloids (two N-oxide glycosides and one D-ring aromatization) (1-3), one verazine-type steroidal alkaloid derivative (4), three solanidine-type steroidal alkaloid glycosides (5-7), and one veratramine-type analogue (8), along with three known compounds (9-11) were isolated from the bulbs of Fritillaria sinica. Their structures were elucidated by comprehensive analysis of spectroscopic data, acidic hydrolysis, and X-ray crystal diffractions. In the in vitro bioassay, the anti-cancer effect, anti-oxidation and anti-inflammatory activities for the isolates were evaluated at a concentration of 10 μM.

Keywords: Anti-cancer effect; Anti-inflammation; Anti-oxidation; Fritillaria sinica; Liliaceae; Steroidal alkaloid derivatives; Zhonghuabeimu.

MeSH terms

Alkaloids* / chemistry
Fritillaria* / chemistry
Glycosides / analysis
Plant Roots / chemistry
Steroids / chemistry

Substances

Alkaloids
Steroids
Glycosides