Progress in metamodulation and receptor-receptor interaction: From physiology to pathology and therapy

Anna Pittaluga; Massimo Grilli; Guendalina Olivero

doi:10.1016/j.neuropharm.2023.109639

Progress in metamodulation and receptor-receptor interaction: From physiology to pathology and therapy

Neuropharmacology. 2023 Oct 1:237:109639. doi: 10.1016/j.neuropharm.2023.109639. Epub 2023 Jun 19.

Authors

Anna Pittaluga¹, Massimo Grilli², Guendalina Olivero³

Affiliations

¹ Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 16148, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, 16145, Genoa, Italy. Electronic address: AnnaMaria.Pittaluga@unige.it.
² Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 16148, Genoa, Italy.
³ Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy.

PMID: 37343628
DOI: 10.1016/j.neuropharm.2023.109639

Abstract

The organization and the role of receptor-receptor interaction (RRI) and metamodulation in physiological conditions have been extensively analyzed and discussed. In this Special Issue of Neuropharmacology, we review recent advances in the understanding of the RRI and the mechanisms underlying its adaptation that could be relevant to the etiopathogenesis of central neuropsychiatric disorders, as well as to the development of new therapeutic approaches to control the activity and to restore the physiological functions, posing the basis for new targeted pharmacological interventions.

Publication types

Editorial