Targeting gasdermin E in neurodegenerative diseases

Cell Rep Med. 2023 Jun 20;4(6):101075. doi: 10.1016/j.xcrm.2023.101075.

Abstract

Neel et al. identified pathophysiologic clues linking gasdermin-E (GSDME) with frontotemporal dementia and amyotrophic lateral sclerosis.1 Therapeutic studies targeting GSDME may provide a viable approach for neurodegenerative diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyotrophic Lateral Sclerosis*
  • Frontotemporal Dementia*
  • Gasdermins
  • Humans
  • Neurodegenerative Diseases*

Substances

  • Gasdermins