ON and OFF receptive field processing in the presence of optical scattering

Katharina Breher; Antonia Neumann; Dominik Kurth; Frank Schaeffel; Siegfried Wahl

doi:10.1364/BOE.489117

ON and OFF receptive field processing in the presence of optical scattering

Biomed Opt Express. 2023 May 11;14(6):2618-2628. doi: 10.1364/BOE.489117. eCollection 2023 Jun 1.

Authors

Katharina Breher^{1

2}, Antonia Neumann², Dominik Kurth², Frank Schaeffel^{2

3}, Siegfried Wahl^{1

2}

Affiliations

¹ Carl Zeiss Vision International GmbH, Turnstr. 27, 73430 Aalen, Germany.
² Institute for Ophthalmic Research, University of Tübingen, Elfriede-Aulhorn-Str. 7, 72076 Tübingen, Germany.
³ Institute of Molecular and Clinical Ophthalmology Basel, Mittlere Str. 91, 4056 Basel, Switzerland.

Abstract

The balance of ON/OFF pathway activation in the retina plays a role in emmetropization. A new myopia control lens design uses contrast reduction to down-regulate a hypothesized enhanced ON contrast sensitivity in myopes. The study thus examined ON/OFF receptive field processing in myopes and non-myopes and the impact of contrast reduction. A psychophysical approach was used to measure the combined retinal-cortical output in the form of low-level ON and OFF contrast sensitivity with and without contrast reduction in 22 participants. ON responses were lower than OFF responses (ON 1.25 ± 0.03 vs. OFF 1.39 ± 0.03 log(CS); p < 0.0001) and myopes showed generally reduced sensitivities (myopes 1.25 ± 0.05 vs. non-myopes 1.39 ± 0.05 log(CS); p = 0.05). These findings remained unaffected by contrast reduction (p > 0.05). The study suggests that perceptual differences in ON and OFF signal processing between myopes and non-myopes exist but cannot explain how contrast reduction can inhibit myopia development.

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