Comprehensive analysis of REST corepressors (RCOR s) in pan-cancer

Rong Zheng; Yingying Pan; Xinhui Liu; Feiye Liu; Aimin Li; Dayong Zheng; Yue Luo

doi:10.3389/fcell.2023.1162344

Comprehensive analysis of REST corepressors (RCOR s) in pan-cancer

Front Cell Dev Biol. 2023 Jun 5:11:1162344. doi: 10.3389/fcell.2023.1162344. eCollection 2023.

Authors

Rong Zheng^{1

2

3}, Yingying Pan^{1

2

3}, Xinhui Liu^{1

2

3}, Feiye Liu^{1

2

3}, Aimin Li^{1

2

3}, Dayong Zheng^{1

2

3}, Yue Luo^{1

2

3}

Affiliations

¹ Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
² Cancer Center, TCM-Integrated Hospital of Southern Medical University, Guangzhou, China.
³ Department of Hepatology, TCM-Integrated Hospital of Southern Medical University, Guangzhou, China.

Abstract

REST corepressors (RCORs) are the core component of the LSD1/CoREST/HDACs transcriptional repressor complex, which have been revealed differently expressed in various cancers, but the therapeutic and prognostic mechanisms in cancer are still poorly understood. In this study, we analyzed expression, prognostic value, molecular subtypes, genetic alteration, immunotherapy response and drug sensitivity of RCORs in pan-cancer. Clinical correlation, stemness index, immune infiltration and regulatory networks of RCORs in hepatocellular carcinoma (HCC) were detected through TCGA and GSCA database. In-vitro experiments were conducted to explore the role of RCOR1 in HCC cells. The expression of RCORs varied among different cancers, and have prognostic values in several cancers. Cancer subtypes were categorized according to the expression of RCORs with clinical information. RCORs were significantly correlated with immunotherapy response, MSI, drug sensitivity and genetic alteration in pan-cancer. In HCC, RCORs were considered as potential predictor of stemness and also had association with immune infiltration. The ceRNA-TF-kinase regulatory networks of RCORs were constructed. Besides, RCOR1 acts as an oncogene in HCC and promotes the proliferation of HCC cells by inhibiting cell cycle arrest and cell apoptosis. Taken together, our study revealed the potential molecular mechanisms of RCORs in pan-cancer, offering a benchmark for disease-related research.

Keywords: HCC; RCORs; biomarker; cell growth; pan-cancer; prognosis.

Grants and funding

This work was supported by National Natural Science Foundation of China (grant nos 81802733 and 82160506); Natural Science Foundation of Guangdong Province (grant no. 2022A1515012620); Science and Technology Program of Guangzhou (grant no. 2023A04J0422); Department of Education of Guangdong Province (grant no. 2022KTSCX023); President’s fund of Integrated hospital of traditional Chinese Medicine (grant no. 1202103008).