Glucose variability: a new risk factor for cardiovascular disease

Acta Diabetol. 2023 Oct;60(10):1291-1299. doi: 10.1007/s00592-023-02097-w. Epub 2023 Jun 21.

Abstract

Aims and data synthesis: Glucose variability (GV) is increasingly considered an additional index of glycemic control. Growing evidence indicates that GV is associated with diabetic vascular complications, thus being a relevant point to address in diabetes management. GV can be measured using various parameters, but to date, a gold standard has not been identified. This underscores the need for further studies in this field also to identify the optimal treatment.

Conclusions: We reviewed the definition of GV, the pathogenetic mechanisms of atherosclerosis, and its relationship with diabetic complications.

Keywords: Atherosclerosis; Cardiovascular diseases; Diabetes; Glucose variability; Hyperglycemia.

Publication types

  • Review

MeSH terms

  • Blood Glucose
  • Cardiovascular Diseases* / complications
  • Cardiovascular Diseases* / etiology
  • Diabetes Mellitus, Type 2* / complications
  • Diabetes Mellitus, Type 2* / epidemiology
  • Diabetic Angiopathies* / complications
  • Diabetic Angiopathies* / etiology
  • Glucose
  • Glycated Hemoglobin
  • Humans
  • Risk Factors

Substances

  • Blood Glucose
  • Glucose
  • Glycated Hemoglobin