Specifics of Experimental Modeling 8-OH-DPAT-Induced Perseverative Behavior in Mice

N V Kudryashov; A V Volkova; A A Shimshirt; P L Naplekova; T A Voronina; S B Seredenin

doi:10.1007/s10517-023-05807-0

Specifics of Experimental Modeling 8-OH-DPAT-Induced Perseverative Behavior in Mice

Bull Exp Biol Med. 2023 May;175(1):41-44. doi: 10.1007/s10517-023-05807-0. Epub 2023 Jun 20.

Authors

N V Kudryashov¹, A V Volkova², A A Shimshirt², P L Naplekova², T A Voronina², S B Seredenin²

Affiliations

¹ V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. kunvi@mail.ru.
² V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.

PMID: 37338756
DOI: 10.1007/s10517-023-05807-0

Abstract

The effect of 5-HT_1A receptor agonist 8-OH-DPAT (intraperitoneal injection in doses of 1, 2, and 4 mg/kg) on spontaneous alternation behavior of mice in Y-maze was studied without and with habituation procedure and food reward. In the first case, 8-OH-DPAT administration led to a decrease in spontaneous alternation and locomotor activity in mice. At the same time, 8-OH-DPAT treatment after habituation and food deprivation increased repeated choices of goal arms without affecting locomotor activity, which was consistent with perseverative behavior. 8-OH-DPAT-induced decrease in spontaneous alternation behavior in Y-maze in mice with habituation and food reward is the most suitable procedure for experimental modeling of the perseverative behavior and studying the anticompulsive activity of new substances.

Keywords: 5-HT1A receptors; 8-OH-DPAT; obsessive-compulsive disorder; perseverative behavior.

MeSH terms

8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology
Animals
Mice
Serotonin Receptor Agonists* / pharmacology

Substances

8-Hydroxy-2-(di-n-propylamino)tetralin
Serotonin Receptor Agonists