Global and regional estimates of cervical cancer burden associated with human immunodeficiency virus infection from 1990 to 2019

Zhengwei Wan; Jianhui Zhao; Liying Xu; Ping Sun; Ping Shuai; Kangning Li; Yixuan Zhang; Yan Chen; Qian Su; Xiaoqin Yao; Xue Li; Yuping Liu

doi:10.1002/jmv.28891

Global and regional estimates of cervical cancer burden associated with human immunodeficiency virus infection from 1990 to 2019

J Med Virol. 2023 Jun;95(6):e28891. doi: 10.1002/jmv.28891.

Authors

Zhengwei Wan^{1

2}, Jianhui Zhao³, Liying Xu³, Ping Sun^{1

2}, Ping Shuai^{1

2}, Kangning Li³, Yixuan Zhang³, Yan Chen^{1

4}, Qian Su^{1

2}, Xiaoqin Yao^{1

2}, Xue Li³, Yuping Liu^{1

2}

Affiliations

¹ Department of Health Management Center, Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
² Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
³ Department of School of Public Health, and Epidemiology and Biostatistics, Zhejiang University School of Medicine, Hangzhou, China.
⁴ School of Public Health, Southwest Medical University, Luzhou, China.

PMID: 37338085
DOI: 10.1002/jmv.28891

Abstract

Previous studies reported human immunodeficiency virus (HIV) could enhance human papillomavirus (HPV)-induced cervical cancer. Therefore, the burden of cervical cancer associated with HIV across different regions and time periods need to be assessed. We aim to investigate the global burden of cervical cancer associated with HIV infection. Age standardized rates (ASRs) of cervical cancer disability-adjusted life-years (DALYs) in females (≥15 years old) were calculated by standardization, according the age-specific DALYs numbers extracted from GBD data set 2019. Population attributable fractions was calculated by combining the published risk ratio, with the HIV prevalence (≥15 years old) from Joint United Nations Programme on HIV and AIDS (UNAIDS), and transferred to estimate the HIV-associated cervical cancer burden. Expected annual percentage changes (EAPCs) was calculated to describe the temporal trend of ASR from 1990 to 2019. Pearson correlation analysis were conducted to assess the correlation between the ASR or EAPCs and the socio-demographic index. The worldwide DALYs ASR caused by HIV-associated cervical cancer rose from 3.78 (95% confidence interval [CI]: 2.19-5.56) in 1990 to 9.50 (95% CI: 5.66-13.79) in 2019 per 100k population. In 2019, the region with the greatest burden was Eastern and Southern Africa, with the highest DALYs of 273 900 (95% CI: 149 100-476 400) and ASR of 254.44 per 100k population (95% CI: 168.86-329.28). Notably, the Eastern Europe and Central Asia regions had the highest EAPC (14.07%) of HIV-associated DALYs ASR. Women in Eastern and Southern Africa experience the greatest burden of HIV-associated cervical cancer, while the Eastern Europe and Central Asia regions had witnessed the largest increase over the last 30 years. Prioritize the promotion of HPV vaccination and cervical cancer screening for women living with HIV were crucial in these regions.

Keywords: cervical cancer; disease burden; human immunodeficiency virus; population attributable fractions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Early Detection of Cancer
Female
Global Burden of Disease
Global Health
HIV
HIV Infections* / complications
HIV Infections* / epidemiology
Humans
Papillomavirus Infections* / complications
Papillomavirus Infections* / epidemiology
Quality-Adjusted Life Years
Uterine Cervical Neoplasms* / epidemiology