Background and objectives: This study examined how a promoter variant of TH (rs10770141) affects subjective effects of cocaine in 65 nontreatment-seeking individuals with cocaine dependence.
Methods: Participants received cocaine/saline intravenously, and TH genotypes were evaluated.
Results: Homozygous individuals for the minor T allele reported greater "good" and "bad" subjective effects to cocaine than those with the major C allele.
Discussion and conclusions: TH rs10770141 modulates subjective effects of cocaine in participants with cocaine dependence.
Scientific significance: These results are among the first to indicate that homozygosity of the T allele of rs10770141 modulates greater sensitivity to cocaine.
© 2023 The American Academy of Addiction Psychiatry (AAAP).