CAR T Cell Therapy: Remedies of Current Challenges in Design, Injection, Infiltration and Working

Drug Des Devel Ther. 2023 Jun 14:17:1783-1792. doi: 10.2147/DDDT.S413348. eCollection 2023.

Abstract

Chimeric antigen receptor (CAR) T cell therapy, as an innovative immunotherapy, plays a huge role in current cancer therapy. Although CAR T cell therapy has demonstrated therapeutic effects in some subtypes of B cell leukemia or lymphoma, there are many challenges that limit the therapeutic efficacy of CAR T cells in solid tumors. And how to efficiently transport CAR T cells to tumor tissues is a continuing concern for us. In this review, experiments have been extensively studied and compared. We finally compared the influence of different injection methods on therapeutic efficacy. We also carefully explored the difficulties of designing, homing, and working of CAR T cells, and ultimately came up with better solutions for each process to help CAR T cells reach tumor tissue more efficiently and quickly. These results will have significant implications for guiding CAR T cell therapy in cancer treatment.

Keywords: CAR T cells; immunotherapy; infiltration; metastasis; tumor microenvironment.

Publication types

  • Review

MeSH terms

  • Humans
  • Immunotherapy
  • Immunotherapy, Adoptive / methods
  • Leukemia, Lymphocytic, Chronic, B-Cell*
  • Neoplasms* / therapy
  • T-Lymphocytes
  • Tumor Microenvironment

Grants and funding

This work was funded by the National Natural Science Foundation of China (NO.82101930, to R.W.), National Natural Science Foundation of China (NO. 61427807, to W.H.) and Discipline construction project of Guangdong Medical University (G622280009, 4SG22260G to W.H). This work was also supported by the China Postdoctoral Science Foundation (No. 2019M662985, to Jianguo Feng).