Psoriasis and Leprosy: An Arcane Relationship

Gai Ge; Jingzhe Shang; Tian Gan; Zhiming Chen; Chun Pan; Youming Mei; Siyu Long; Aiping Wu; Hongsheng Wang

doi:10.2147/JIR.S407650

Psoriasis and Leprosy: An Arcane Relationship

J Inflamm Res. 2023 Jun 14:16:2521-2533. doi: 10.2147/JIR.S407650. eCollection 2023.

Authors

Gai Ge¹, Jingzhe Shang^{2

3}, Tian Gan¹, Zhiming Chen¹, Chun Pan¹, Youming Mei¹, Siyu Long⁴, Aiping Wu^{2

3}, Hongsheng Wang^{1

5

6}

Affiliations

¹ Laboratory of Mycobacteria, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, People's Republic of China.
² Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
³ Suzhou Institute of Systems Medicine, Suzhou, People's Republic of China.
⁴ Department of Dermatology, Beijing Chao-Yang Hospital & Capital Medical University, Beijing, People's Republic of China.
⁵ National Center for Sexually Transmitted Disease and Leprosy Control, China Centers for Disease Control and Prevention, Nanjing, People's Republic of China.
⁶ Centre for Global Health, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.

Abstract

Purpose: Psoriasis (Ps) and leprosy are chronic inflammatory skin disorders, characterised by enhanced innate and adaptive immunity. Ps and leprosy rarely coexist. The molecular immune mechanism of the Ps and leprosy rarely coexistence is unclear.

Patients and methods: RNA-sequencing (RNA-seq) was performed on 20 patients with Ps, 5 adults with lepromatous leprosy (L-lep), and 5 patients with tuberculoid leprosy (T-lep) to analyse the differentially expressed genes (DEGs) between them. Moreover, the biological mechanism of Ps and leprosy was explored by Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Gene Ontology (GO) analysis, Gene Set Enrichment Analysis analysis, and protein-protein interaction (PPI) analyses. Finally, 13 DEGs of 10 skin biopsies of Ps patients, 6 samples of L-lep patients, 6 samples of T-lep patients and 5 healthy controls were confirmed by quantitative real-time polymerase chain reaction (qRT-PCR).

Results: The PPI network was constructed and primarily associated with immune response, IL-17 signalling, and Toll-like receptor pathway between Ps and leprosy. Th17 markers (interleukin (IL)-19, IL-20, IL-36A, IL-36G, IL-22, IL-17A, and lipocalin-2 (LCN2) had higher expression in Ps than in L-lep and T-lep, whereas macrophage biomarkers (CLEC4E and TREM2), SPP1, and dendritic cell (DC)-related hallmarks (ITGAX) and TNF-a had significantly lower expression across Ps and T-lep than in L-lep.

Conclusion: To put it simply, Ps patients with IL-17A, IL-19, IL-20, IL-36A, IL-36G, and IL-22 in conjunction with LCN2 with up-graduated expression might be not susceptible to L-lep. However, high levels of CLEC4E, TREM2, and SPP1 in L-lep patients indicated that they unlikely suffered from Ps.

Keywords: CLEC4E; IL-17A; Th17 cell; leprosy; macrophage; psoriasis.

Grants and funding

This study was supported by grants from the National Key R&D Program of China (grant number 2019YFE0113300), National Natural Science Foundation of China (grant numbers 81972950, 82173431, 82103748), the Nanjing Incubation Program for National Clinical Research Center (grant number 2019060001), Chinese Academy of Medical Sciences Innovation Fund for Medical Science (2022-I2M-C&T-B-094).