Liposome-anchored mesenchymal stem cells for radiation pneumonia/fibrosis treatment

Hailin Zhou; Yanxiang Zhang; Pei Pei; Wenhao Shen; Xuan Yi; Kai Yang

doi:10.1016/j.biomaterials.2023.122202

Liposome-anchored mesenchymal stem cells for radiation pneumonia/fibrosis treatment

Biomaterials. 2023 Sep:300:122202. doi: 10.1016/j.biomaterials.2023.122202. Epub 2023 Jun 14.

Authors

Hailin Zhou¹, Yanxiang Zhang¹, Pei Pei¹, Wenhao Shen¹, Xuan Yi², Kai Yang³

Affiliations

¹ State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu, 215123, China.
² School of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong, Jiangsu, 226001, China. Electronic address: xuanyi@ntu.edu.cn.
³ State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu, 215123, China. Electronic address: kyang@suda.edu.cn.

PMID: 37336116
DOI: 10.1016/j.biomaterials.2023.122202

Abstract

The effectiveness of mesenchymal stem cells (MSCs) on inflammation-related disease is limited and the pharmaceutical preparation that was used to enhance the efficacy of MSCs cannot reach the diseased tissue in large quantities. Herein, antioxidant liposome (Lipo-OPC) is designed to anchor onto the surface of MSCs membrane via click chemical reaction (MSC-Lipo-OPC) without affecting the viability and physiological characteristics of MSCs, thus allowing efficient accumulation of MSC-Lipo-OPC in X-ray irradiated lung sites. More importantly, MSC-Lipo-OPC promotes the change of the quantity and polarity of innate immunocytes, mainly including neutrophils, macrophages and Tregs, in favor of anti-inflammatory, finally preventing the formation of radioactive pulmonary fibrosis. Therefore, it could enhance the treatment outcome of both of MSCs and drugs to radiation-induced lung injury via modifying the drug-loaded nanoparticle on the surface of MSCs membrane, further promoting the application of MSCs in radiation damage and protection.

Keywords: Anti-inflammatory immune; Click chemical reaction; Mesenchymal stem cells; Radiation pneumonia/fibrosis; Reactive oxygen species.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Liposomes
Lung Injury*
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells*
Pulmonary Fibrosis* / therapy
Radiation Pneumonitis* / therapy

Substances

Liposomes