Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells

Tinglin Song; Jiaye Chen; Sizhu Yang; Boqun Liu; Lingling Zhang; Qian Zhang; Jung-Chien Cheng; Lanlan Fang

doi:10.38212/2224-6614.3460

Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells

J Food Drug Anal. 2023 Jun 15;31(2):315-325. doi: 10.38212/2224-6614.3460.

Authors

Tinglin Song¹, Jiaye Chen¹, Sizhu Yang¹, Boqun Liu¹, Lingling Zhang¹, Qian Zhang¹, Jung-Chien Cheng¹, Lanlan Fang¹

Affiliation

¹ Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Abstract

Steroidogenic acute regulatory protein (StAR) plays a critical role in the regulation of progesterone (P4) production. Resveratrol (RSV), a natural polyphenol, has beneficial effects on reproductive function. However, its effects on StAR expression and P4 production in human granulosa cells remain undetermined. In this study, we showed that treatment of RSV upregulated StAR expression in human granulosa cells. G protein-coupled estrogen receptor (GPER) and ERK1/2 signaling were involved in RSV-stimulated StAR expression and P4 production. In addition, the expression of a transcriptional repressor, Snail, was downregulated by RSV, which contributed to the RSV-induced inductions of StAR expression and P4 production.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Down-Regulation
Female
Granulosa Cells* / metabolism
Humans
Progesterone* / metabolism
Progesterone* / pharmacology
Resveratrol / metabolism
Resveratrol / pharmacology

Substances

Progesterone
Resveratrol
steroidogenic acute regulatory protein

Grants and funding

This work was supported by operating grants (32070848 to Lanlan Fang and 32170868 to Jung-Chien Cheng) from the National Natural Science Foundation of China. This work was also supported by the Henan Health Science and Technology Innovation Program for Distinguished Young Scholars from the Henan Health Commission (YXKC2022027) and Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University (QNCXTD2023011) to Lanlan Fang.