Associations of Dietary Intakes of Total and Specific Types of Fat with Blood Lipid Levels in the Filipino Women's Diet and Health Study (FiLWHEL)

Heejin Lee; Hyojin Kim; Sherlyn Mae P Provido; Minji Kang; Grace H Chung; Jae W Lee; Sangmo Hong; Sung Hoon Yu; Chang Beom Lee; Jung Eun Lee

doi:10.5334/gh.1209

Associations of Dietary Intakes of Total and Specific Types of Fat with Blood Lipid Levels in the Filipino Women's Diet and Health Study (FiLWHEL)

Glob Heart. 2023 Jun 12;18(1):29. doi: 10.5334/gh.1209. eCollection 2023.

Authors

Heejin Lee¹, Hyojin Kim¹, Sherlyn Mae P Provido², Minji Kang³, Grace H Chung⁴, Jae W Lee⁵, Sangmo Hong⁶, Sung Hoon Yu⁶, Chang Beom Lee⁶, Jung Eun Lee^{1

2}

Affiliations

¹ Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Republic of Korea.
² Research Institute of Human Ecology, Seoul National University, Seoul, Republic of Korea.
³ Department of Food and Nutrition, Duksung Women's University, Seoul, Republic of Korea.
⁴ Child Development and Family Studies, College of Human Ecology, Seoul National University, Seoul, Republic of Korea.
⁵ Department of Computer Science and Engineering, Seoul National University, Seoul, Republic of Korea.
⁶ Division of Endocrinology and Metabolism, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Republic of Korea.

Abstract

Background: Limited evidence exists on the association between dietary fat intake and lipid profiles in Southeast Asian populations.

Objectives: We aimed to examine the cross-sectional associations of dietary intake of total and specific types of fat with dyslipidemia in Filipino immigrant women in Korea.

Methods: We included 406 Filipino women married to Korean in the Filipino Women's Diet and Health Study (FiLWHEL). Dietary fat intake was assessed using 24-hour recalls. Impaired blood lipid profiles were defined as high total cholesterol (TC) (≥200 mg/dL), high triglyceride (TG) (≥150 mg/dL), high LDL Cholesterol (LDL-C) (≥ 130 mg/dL), or low HDL cholesterol (HDL-C) (<50 mg/dL). The genomic DNA samples were genotyped using DNA chip. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate logistic regression.

Results: Substituting carbohydrates with dietary saturated fat (SFA) intake was associated with increased prevalence of dyslipidemia; ORs (95% CIs) for subsequent tertiles compared to the first tertile were 2.28 (1.19-4.35), and 2.88 (1.29-6.39) (P for trend = 0.02). When we examined individual markers, ORs (95% CIs, P for trend) comparing the third to the first tertile were 3.62 (1.53-8.55, 0.01) for high TC, 1.46 (0.42-5.10, 0.72) for high TG, 4.00 (1.48-10.79, 0.02) for high LDL-C, and 0.69 (0.30-1.59, 0.36) for low HDL-C. When we examined the interaction by LDL-C-related polymorphisms, the association with dyslipidemia was more pronounced among participants with CC alleles than among those with T alleles of rs6102059 (P for interaction = 0.01).

Conclusions: High dietary SFA intake was significantly associated with a high prevalence of dyslipidemia in Filipino women in Korea. Further prospective cohort studies are warranted to determine risk factors for CVD in Southeast Asian populations.

Keywords: Dyslipidemia; Filipino women; fat intake.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cholesterol, HDL
Cholesterol, LDL
Cross-Sectional Studies
Diet
Dietary Fats / adverse effects
Dyslipidemias* / epidemiology
Eating
Female
Humans
Lipids*
Triglycerides

Substances

Cholesterol, LDL
Lipids
Dietary Fats
Cholesterol, HDL
Triglycerides

Grants and funding

This work was supported by Seoul National University Research Grant in 2019, the Hanmi Pharmaceutical Co., Ltd., (No. 201300000001270), Chong Kun Dang Pharm., Seoul, Korea, (No. 201600000000225), the Handok Inc., Seoul, Korea, and Yuhan Corporation.