Influences of resolvin D1 and D2 on the risk of type 2 diabetes mellitus: a Chinese community-based cohort study

Qian Sun; Junrong Wang; Yang Jing; Jingchao Liu; Jianrong Jin; Sudan Wang; Jin Zhang; Kaili Liu; Xiaofang Chen; Hui Zhou; Chen Dong

doi:10.3389/fimmu.2023.1143456

Influences of resolvin D1 and D2 on the risk of type 2 diabetes mellitus: a Chinese community-based cohort study

Front Immunol. 2023 Jun 2:14:1143456. doi: 10.3389/fimmu.2023.1143456. eCollection 2023.

Authors

Qian Sun¹, Junrong Wang¹, Yang Jing², Jingchao Liu³, Jianrong Jin³, Sudan Wang¹, Jin Zhang¹, Kaili Liu¹, Xiaofang Chen², Hui Zhou², Chen Dong¹

Affiliations

¹ Department of Epidemiology and Statistics, School of Public Health, Medical College of Soochow University, Soochow, Jiangsu, China.
² Division of Non-communicable Diseases, Suzhou Industrial Park Centers for Disease Control and Prevention, Soochow, China.
³ Division of Non-communicable Diseases, Suzhou Wuzhong Centers for Disease Control and Prevention, Soochow, China.

Abstract

Background: Although cellular and animal studies have reported that resolvin D1 (RvD1) and resolvin D2 (RvD2) are mechanisms involved in the development of type 2 diabetes mellitus (T2DM), the impact of RvD1 and RvD2 on the risk of T2DM at a population level remains unclear.

Methods: We included 2755 non-diabetic adults from a community-based cohort in China and followed them for seven years. Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of RvD1 and RvD2 with T2DM probability. Time-dependent receiver operator characteristics (ROC) curve was used to evaluate the predictive performance of RvD1 and RvD2 for the risk of T2DM based on the Chinese CDC T2DM prediction model (CDRS).

Results: A total of 172 incident T2DM cases were identified. Multivariate-adjusted HRs (95% CI) for T2DM across quartiles of RvD1 levels (Q1, Q2, Q3 and Q4) were 1.00, 1.64 (1.03-2.63), 1.80 (1.13-2.86) and 1.61 (1.01-2.57), respectively. Additionally, body mass index (BMI) showed a significant effect modification in the association of RvD1 with incident T2DM (P _interaction = 0.026). After multivariate adjustment, the HR (95% CI) for T2DM in the fourth compared with the first quartile of RvD2 was 1.94 (95% CI: 1.24-3.03). Time-dependent ROC analysis showed that the area under time-dependent ROC curves of the "CDRS+RvD1+RvD2" model for the 3-, 5- and 7-year risk of T2DM were 0.842, 0.835 and 0.828, respectively.

Conclusions: Higher RvD1 and RvD2 levels are associated with a higher risk of T2DM at the population level.

Keywords: association; cohort study; resolvin D1; resolvin D2; type 2 diabetes mellitus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Body Mass Index
Cohort Studies
Diabetes Mellitus, Type 2* / epidemiology
East Asian People
Humans

Substances

resolvin D1
resolvin D2

Grants and funding

This work was supported by the National Natural Science Foundation of China (No. 81773507, 82173594), Key University Science Research Project of Jiangsu Province (21KJA330003), Suzhou health personnel training project (GSWS2020120), Key technologies of prevention and control of major diseases and infectious diseases in Suzhou City (Gwzx202103), Suzhou science and technology development plan project (SS202009, SKJYD2021049).