Maternal Breast Milk Secretor Phenotype Does Not Affect Infant Susceptibility to Rotavirus Diarrhea

Frank B Williams; Md Abdul Kader; Dorothy M Dickson; E Ross Colgate; Masud Alam; Rashidul Haque; William A Petri Jr; Beth D Kirkpatrick; Benjamin Lee

doi:10.1093/ofid/ofad299

Maternal Breast Milk Secretor Phenotype Does Not Affect Infant Susceptibility to Rotavirus Diarrhea

Open Forum Infect Dis. 2023 Jun 7;10(6):ofad299. doi: 10.1093/ofid/ofad299. eCollection 2023 Jun.

Authors

Frank B Williams¹, Md Abdul Kader², Dorothy M Dickson¹, E Ross Colgate¹, Masud Alam², Rashidul Haque², William A Petri Jr³, Beth D Kirkpatrick¹, Benjamin Lee¹

Affiliations

¹ Vaccine Testing Center and Translational Global Infectious Diseases Research Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
² International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
³ Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.

Abstract

Breast milk secretor status is associated with antibody seroconversion to oral rotavirus vaccination. Here, we were unable to detect a similar impact on risk of infant rotavirus diarrhea or vaccine efficacy through 2 years of life, underscoring limitations of immunogenicity assessment alone in evaluation of oral rotavirus vaccine response.

Keywords: breast milk; oral vaccination; rotavirus; secretor status.

Abstract

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