TRP channels: Role in neurodegenerative diseases and therapeutic targets

Mashoque Ahmad Rather; Andleeb Khan; Lianchun Wang; Sadaf Jahan; Muneeb U Rehman; Hafiz A Makeen; Syam Mohan

doi:10.1016/j.heliyon.2023.e16910

TRP channels: Role in neurodegenerative diseases and therapeutic targets

Heliyon. 2023 Jun 2;9(6):e16910. doi: 10.1016/j.heliyon.2023.e16910. eCollection 2023 Jun.

Authors

Mashoque Ahmad Rather¹, Andleeb Khan², Lianchun Wang¹, Sadaf Jahan³, Muneeb U Rehman⁴, Hafiz A Makeen⁵, Syam Mohan^{6

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Affiliations

¹ Department of Molecular Pharmacology & Physiology, Bryd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, United States.
² Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
³ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majma'ah, 11952, Saudi Arabia.
⁴ Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
⁵ Pharmacy Practice Research Unit, Department of Pharmacy Practice, College of Pharmacy, Jazan University, 45142, Saudi Arabia.
⁶ Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, Saudi Arabia.
⁷ School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India.
⁸ Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, India.

Abstract

TRP (Transient receptor potential) channels are integral membrane proteins consisting of a superfamily of cation channels that allow permeability of both monovalent and divalent cations. TRP channels are subdivided into six subfamilies: TRPC, TRPV, TRPM, TRPP, TRPML, and TRPA, and are expressed in almost every cell and tissue. TRPs play an instrumental role in the regulation of various physiological processes. TRP channels are extensively represented in brain tissues and are present in both prokaryotes and eukaryotes, exhibiting responses to several mechanisms, including physical, chemical, and thermal stimuli. TRP channels are involved in the perturbation of Ca²⁺ homeostasis in intracellular calcium stores, both in neuronal and non-neuronal cells, and its discrepancy leads to several neuronal disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Amyotrophic lateral sclerosis (ALS). TRPs participate in neurite outgrowth, receptor signaling, and excitotoxic cell death in the central nervous system. Understanding the mechanism of TRP channels in neurodegenerative diseases may extend to developing novel therapies. Thus, this review articulates TRP channels' physiological and pathological role in exploring new therapeutic interventions in neurodegenerative diseases.

Keywords: Alzheimer's disease; Amyotrophic lateral sclerosis; Ca2+ homeostasis; Huntington's disease; Parkinson's disease; TRP.

Publication types

Review