Multisystem Inflammatory Syndrome in Children and Kawasaki Disease: A Spectrum of Postinfectious Hyperinflammatory Disease

Rheum Dis Clin North Am. 2023 Aug;49(3):661-678. doi: 10.1016/j.rdc.2023.03.003. Epub 2023 Apr 15.

Abstract

Kawasaki disease and multisystem inflammatory syndrome in children are hyperinflammatory conditions that share similar emerging pathophysiology hypotheses, clinical features, treatment strategies, and outcomes. Although both conditions have key differences, growing evidence suggests that both conditions might be closely related on a larger spectrum of postinfectious autoimmune responses.

Keywords: COVID-19; Kawasaki disease; MIS-C; Vasculitis.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • COVID-19*
  • Child
  • Humans
  • Mucocutaneous Lymph Node Syndrome* / complications
  • Mucocutaneous Lymph Node Syndrome* / diagnosis
  • Post-Infectious Disorders
  • Systemic Inflammatory Response Syndrome / diagnosis
  • Systemic Inflammatory Response Syndrome / etiology
  • Systemic Inflammatory Response Syndrome / therapy

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related