Comparing fast-acting interventions for treatment-resistant depression: An explorative study of accelerated HF-rTMS versus intranasal esketamine

Mauro Pettorruso; Giacomo d'Andrea; Francesco Di Carlo; Luisa De Risio; Francesca Zoratto; Andrea Miuli; Beatrice Benatti; Matteo Vismara; Enrico Pompili; Giuseppe Nicolò; Cinzia Niolu; Alberto Siracusano; Stefano S Sensi; Bernardo Dell'Osso; Giorgio Di Lorenzo; Giovanni Martinotti; ReModula Study Group

doi:10.1016/j.brs.2023.06.003

Comparing fast-acting interventions for treatment-resistant depression: An explorative study of accelerated HF-rTMS versus intranasal esketamine

Brain Stimul. 2023 Jul-Aug;16(4):1041-1043. doi: 10.1016/j.brs.2023.06.003. Epub 2023 Jun 17.

Authors

Mauro Pettorruso¹, Giacomo d'Andrea², Francesco Di Carlo³, Luisa De Risio⁴, Francesca Zoratto⁵, Andrea Miuli⁶, Beatrice Benatti⁷, Matteo Vismara⁷, Enrico Pompili⁴, Giuseppe Nicolò⁴, Cinzia Niolu⁸, Alberto Siracusano⁸, Stefano S Sensi³, Bernardo Dell'Osso⁷, Giorgio Di Lorenzo⁹, Giovanni Martinotti¹⁰; ReModula Study Group

Collaborators

ReModula Study Group:
Giulia Giovannetti, Giulia Stefanelli, Clara Cavallotto, Ottavia Susini, Rosalba Carullo, Gianluca Mancusi, Ornella Di Marco, Mario Santorelli, Fabrizio Martino, Alessia Nicita, Laura Bernabei, Federica Tarallo, Alessandra Corrado, Luca Carlone

Affiliations

¹ Department of Neurosciences, Imaging and Clinical Sciences, Università Degli Studi G. D'Annunzio, Chieti, Italy; Department of Mental Health, ASL 2 Abruzzo Lanciano-Vasto-Chieti, Chieti, Italy.
² Department of Neurosciences, Imaging and Clinical Sciences, Università Degli Studi G. D'Annunzio, Chieti, Italy. Electronic address: giacomo.dandrea1993@gmail.com.
³ Department of Neurosciences, Imaging and Clinical Sciences, Università Degli Studi G. D'Annunzio, Chieti, Italy.
⁴ Department of Mental Health and Addiction, ASL Roma 5, Rome, Italy.
⁵ Centre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy; Unit of Cognitive Primatology, Institute of Cognitive Sciences and Technologies, National Research Council of Italy, Via Ulisse Aldrovandi 16/b, 00197, Rome, Italy.
⁶ Department of Mental Health, ASL 2 Abruzzo Lanciano-Vasto-Chieti, Chieti, Italy.
⁷ Department of Biomedical and Clinical Sciences Luigi Sacco and Aldo Ravelli Center for Neurotechnology and Brain Therapeutic, University of Milan, Milano, Italy.
⁸ Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
⁹ Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; IRCCS Fondazione Santa Lucia, Rome, Italy.
¹⁰ Department of Neurosciences, Imaging and Clinical Sciences, Università Degli Studi G. D'Annunzio, Chieti, Italy; Department of Mental Health, ASL 2 Abruzzo Lanciano-Vasto-Chieti, Chieti, Italy; Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, AL10 9AB, UK.

PMID: 37331507
DOI: 10.1016/j.brs.2023.06.003

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antidepressive Agents / therapeutic use
Depression
Depressive Disorder, Treatment-Resistant* / therapy
Humans
Ketamine* / pharmacology
Ketamine* / therapeutic use
Transcranial Magnetic Stimulation
Treatment Outcome

Substances

Esketamine
Antidepressive Agents
Ketamine