Case Report of Anti-Thrombogenicity

Blood Purif. 2023 Jun 16:1-3. doi: 10.1159/000530850. Online ahead of print.

Abstract

Background: The Toray Filtryzer™-NF is a new polymethyl methacrylate filter with improved hemocompatibility and reduced impact on platelet counts.

Objectives: This suggests that, if necessary, a reduction in anticoagulation may be possible when dialysis is performed with the Toray Filtryzer™-NF.

Methods: In the following, we dialyzed 5 hemodialysis patients who had a contraindication to full anticoagulation postoperatively or after renal biopsy with the Filtryzer™-NF.

Results: A significant reduction in heparin administration was achieved, and in 1 patient, heparin substitution was completely omitted. Despite the significantly reduced heparin doses, no thrombosis of the system occurred during the hemodialysis.

Conclusion: In conclusion, hemodialysis using the Toray Filtryzer™-NF is an effective alternative for patients at significantly increased risk of bleeding.

Keywords: Anticoagulation; Citrate anticoagulation; Polymethyl methacrylate; Risk of bleeding.

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