Synergy between Th1 and Th2 responses during endometriosis: A review of current understanding

Ling-Yu Chang; Jing Shan; Xin-Xin Hou; Da-Jin Li; Xiao-Qiu Wang

doi:10.1016/j.jri.2023.103975

Synergy between Th1 and Th2 responses during endometriosis: A review of current understanding

J Reprod Immunol. 2023 Aug:158:103975. doi: 10.1016/j.jri.2023.103975. Epub 2023 Jun 7.

Authors

Ling-Yu Chang¹, Jing Shan¹, Xin-Xin Hou², Da-Jin Li³, Xiao-Qiu Wang⁴

Affiliations

¹ Hospital of Obstetrics and Gynecology, Fudan University, Shanghai Medical College, Shanghai 200011, China.
² Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
³ Hospital of Obstetrics and Gynecology, Fudan University, Shanghai Medical College, Shanghai 200011, China. Electronic address: djli@shmu.edu.cn.
⁴ Hospital of Obstetrics and Gynecology, Fudan University, Shanghai Medical College, Shanghai 200011, China. Electronic address: michelleqiuqiu@163.com.

PMID: 37331087
DOI: 10.1016/j.jri.2023.103975

Abstract

Endometriosis is widely perceived as an estrogen-dependent chronic disorder with infertility and pelvic pain. Although the etiology of endometriosis has remained elusive, many studies have proclaimed the relevance of immune system disorders with endometriosis. With the discovery that the dysregulation of multiple biological functions in endometriosis is caused by the aberrant differentiation of T helper cells, a shift towards Th2 immune response may account for the disease progression. This review attempts to present mechanisms of cytokines, chemokines, signal pathways, transcription factors and some other factors related with the derivation of Th1/Th2 immune response involved in the development of endometriosis. The current understanding of treatment approaches and potential therapeutic targets will also be outlined with brief discussion.

Keywords: Chemokine; Cytokine; Endometriosis; Signaling pathway; Th1/Th2 immune response.

Publication types

Review