Low beta-band suppression as a tool for DBS contact selection for akinetic-rigid symptoms in Parkinson's disease

Joshua N Strelow; Till A Dembek; Juan C Baldermann; Pablo Andrade; Gereon R Fink; Veerle Visser-Vandewalle; Michael T Barbe

doi:10.1016/j.parkreldis.2023.105478

Low beta-band suppression as a tool for DBS contact selection for akinetic-rigid symptoms in Parkinson's disease

Parkinsonism Relat Disord. 2023 Jul:112:105478. doi: 10.1016/j.parkreldis.2023.105478. Epub 2023 Jun 12.

Authors

Joshua N Strelow¹, Till A Dembek², Juan C Baldermann³, Pablo Andrade⁴, Gereon R Fink⁵, Veerle Visser-Vandewalle⁴, Michael T Barbe²

Affiliations

¹ University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Stereotactic and Functional Neurosurgery, Cologne, Germany. Electronic address: joshua.strelow@uk-koeln.de.
² University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, Cologne, Germany.
³ University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Psychiatry and Psychotherapy, Cologne, Germany.
⁴ University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Stereotactic and Functional Neurosurgery, Cologne, Germany.
⁵ University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, Cologne, Germany; Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Jülich Research Center, Jülich, Germany.

PMID: 37331065
DOI: 10.1016/j.parkreldis.2023.105478

Abstract

Background: Suppression of pathologically altered activity in the beta-band has previously been suggested as a biomarker for feedback-based neurostimulation in subthalamic deep brain stimulation (STN-DBS) for Parkinson's Disease (PD).

Objective: To assess the utility of beta-band suppression as a tool for contact selection in STN-DBS for PD.

Methods: A sample of seven PD patients (13 hemispheres) with newly implanted directional DBS leads of the STN were recorded during a standardized monopolar contact review (MPR). Recordings were received from contact pairs adjacent to the stimulation contact. The degree of beta-band suppression for each investigated contact was then correlated to the respective clinical results. Additionally, we have implemented a cumulative ROC analysis, to test the predictive value of beta-band suppression on the clinical efficacy of the respective contacts.

Results: Stimulation ramping led to frequency-specific changes in the beta-band, while lower frequencies remained unaffected. Most importantly, our results showed that the degree of low beta-band suppression from baseline activity (stimulation off) served as a predictor for clinical efficacy of the respective stimulation contact. In contrast suppression of high beta-band activity yielded no predictive power.

Conclusion: The degree of low beta-band suppression can serve as a time-saving, objective tool for contact selection in STN-DBS.

Keywords: DBS programming; Deep brain stimulation (DBS); Local field potential (LFP); Nucleus subthalamicus (STN).

MeSH terms

Deep Brain Stimulation* / methods
Humans
Parkinson Disease* / therapy
Subthalamic Nucleus* / physiology
Treatment Outcome