The two faces of DJ-1D proteins

Priya Gambhir; Arun Kumar Sharma; Rahul Kumar

doi:10.1016/j.tplants.2023.06.005

The two faces of DJ-1D proteins

Trends Plant Sci. 2023 Oct;28(10):1089-1091. doi: 10.1016/j.tplants.2023.06.005. Epub 2023 Jun 15.

Authors

Priya Gambhir¹, Arun Kumar Sharma¹, Rahul Kumar²

Affiliations

¹ Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India.
² Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India. Electronic address: rksl@uohyd.ac.in.

PMID: 37330357
DOI: 10.1016/j.tplants.2023.06.005

Abstract

Despite the documented bi-enzymatic mode of methylglyoxal detoxification, the single-step catalysis of methylglyoxal by DJ-1/Pfp-I domain containing proteins has been in the limelight. Prasad et al. recently discovered another functional facet of these moonlighting proteins: the deglycase potential of DJ-1D to repair the glycated DNA, RNA, and proteins in plants.

Keywords: DNA repair; deglycase; glyoxalase; methylglyoxal; stress tolerance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Pyruvaldehyde* / metabolism

Substances

Pyruvaldehyde