1 Department of Health Policy, Institute for Pharmacological Research Mario Negri IRCCS, Milan, Italy.
2 Institute of Clinical Trials and Methodology, University College London, London, UK.
3 Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. piermannuccio.mannucci@policlinico.mi.it.