Pharmacogenetic testing in psychiatry: Perspective on clinical utility

Frances Adiukwu; Olufisayo Adesokun; Emmanuel Essien; Nadir Yalcin; Ramdas Ransing; Sachin Nagendrappa; Chonnakarn Jatchavala; Ayotunde Bolatito Olakunke; Faisal A Nawaz; Nagina Khan

doi:10.1016/j.ajp.2023.103674

Pharmacogenetic testing in psychiatry: Perspective on clinical utility

Asian J Psychiatr. 2023 Aug:86:103674. doi: 10.1016/j.ajp.2023.103674. Epub 2023 Jun 12.

Authors

Affiliations

¹ Department of Mental Health, University of Port Harcourt, Rivers State, Nigeria. Electronic address: frances.adiukwu@uniport.edu.ng.
² Department of Neuropsychiatry, University of Port Harcourt Teaching Hospital, Rivers State, Nigeria. Electronic address: adesaayo@gmail.com.
³ Department of Psychiatry, University of Calabar, Calabar, Nigeria. Electronic address: mannyessien@gmail.com.
⁴ Department of Clinical Pharmacology, Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey. Electronic address: nadir.yalcin@hacettepe.edu.tr.
⁵ Department of Psychiatry, Clinical Neurosciences and Addiction Medicine, All India Institute of Medical Sciences, Guwahati, Assam 781101, India. Electronic address: ramdas_ransing123@yahoo.co.in.
⁶ St Johns Medical College Hospital, Bangaluru 34, India. Electronic address: sachin.n@stjohns.in.
⁷ Department of Psychiatry, Faculty of Medicine, Prince Songkhla University, Songkhla 90110, Thailand. Electronic address: jchonnak@gmail.com.
⁸ Child and Adolescent Psychiatry Unit, Department of Behavioural Sciences, University of Ilorin/ University of Ilorin Teaching Hospital, Ilorin, Nigeria.
⁹ Department of Psychiatry, Al Amal Psychiatric Hospital, Dubai, United Arab Emirates. Electronic address: faisal.nawaz@ehs.gov.ae.
¹⁰ CHiMES Collaborative, Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford OX3 7JX, UK. Electronic address: nagina.khan@psych.ox.ac.uk.

PMID: 37327563
DOI: 10.1016/j.ajp.2023.103674

Abstract

Pharmacogenetic studies the influence of inherited characteristics on medication. While different from pharmacogenomics, which is a study of the entire genome in relation to medication effect, their distinction remains inconsistent, and the two terms are used interchangeably. Although the potential of pharmacogenomics in psychiatry is apparent and its clinical utility is suboptimal, the uptake of recommendations and guidelines is minimal and research into PGx is not diverse. This article offers an overview of pharmacogenetics (PGx) in psychiatry, explores the difficulties, and provides recommendations on improving its applicability and clinical utility.

Keywords: Pharmacogenomics; Precision medicine; Psychiatry PGx.

MeSH terms

Humans
Pharmacogenetics
Pharmacogenomic Testing*
Psychiatry*