Ferroptosis-mediated immune responses in cancer

Desheng Qi; Milin Peng

doi:10.3389/fimmu.2023.1188365

Ferroptosis-mediated immune responses in cancer

Front Immunol. 2023 May 30:14:1188365. doi: 10.3389/fimmu.2023.1188365. eCollection 2023.

Authors

Desheng Qi^{1

2}, Milin Peng^{2

3}

Affiliations

¹ Department of Emergency, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan, China.
³ Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Abstract

Cell death is a universal biological process in almost every physiological and pathological condition, including development, degeneration, inflammation, and cancer. In addition to apoptosis, increasing numbers of cell death types have been discovered in recent years. The biological significance of cell death has long been a subject of interest and exploration and meaningful discoveries continue to be made. Ferroptosis is a newfound form of programmed cell death and has been implicated intensively in various pathological conditions and cancer therapy. A few studies show that ferroptosis has the direct capacity to kill cancer cells and has a potential antitumor effect. As the rising role of immune cells function in the tumor microenvironment (TME), ferroptosis may have additional impact on the immune cells, though this remains unclear. In this study we focus on the ferroptosis molecular network and the ferroptosis-mediated immune response, mainly in the TME, and put forward novel insights and directions for cancer research in the near future.

Keywords: cancer immunotherapy; cell death; ferroptosis; immunity; tumor microenvironment (TME).

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Cell Death
Ferroptosis*
Humans
Inflammation
Neoplasms*
Tumor Microenvironment

Grants and funding

The funding of the study was supported by the National Natural Science Foundation of China (grant numbers 82102282); Natural Science Foundation of Hunan Province (grant numbers 2022JJ30953); China Postdoctoral Science Foundation (grant numbers 2022M713528) and the Natural Science Foundation of Changsha City (grant numbers kq2202381).