TGFβ signaling pathways in human health and disease

Pei-Yu Chen; Lingfeng Qin; Michael Simons

doi:10.3389/fmolb.2023.1113061

TGFβ signaling pathways in human health and disease

Front Mol Biosci. 2023 Jun 1:10:1113061. doi: 10.3389/fmolb.2023.1113061. eCollection 2023.

Authors

Pei-Yu Chen¹, Lingfeng Qin², Michael Simons^{1

3}

Affiliations

¹ Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States.
² Department of Surgery, Yale University School of Medicine, New Haven, CT, United States.
³ Department of Cell Biology, Yale University School of Medicine, New Haven, CT, United States.

Abstract

Transforming growth factor beta (TGFβ) is named for the function it was originally discovered to perform-transformation of normal cells into aggressively growing malignant cells. It became apparent after more than 30 years of research, however, that TGFβ is a multifaceted molecule with a myriad of different activities. TGFβs are widely expressed with almost every cell in the human body producing one or another TGFβ family member and expressing its receptors. Importantly, specific effects of this growth factor family differ in different cell types and under different physiologic and pathologic conditions. One of the more important and critical TGFβ activities is the regulation of cell fate, especially in the vasculature, that will be the focus of this review.

Keywords: EndMT; RNAi; TGFβ; aneurysm; cell fate; endothelail cell; nanoparticle; smooth muscle cell.

Publication types

Review

Grants and funding

This work was supported, in part, by a Cardiovascular Medical Research Education Fund (P-YC), Loeys-Dietz Syndrome Foundation Canada LEAP Impact Award (P-YC), Friedreich’s Ataxia Research Alliance Award for Innovative Mindset (P-YC), Vasculitis Foundation Young Investigator Program (P-YC), NIH grants HL135582 (MS), HL152197 (MS), and Open Philanthropy Foundation (MS).