CuFe2O4 nanoparticles-based electrochemical sensor for sensitive determination of the anticancer drug 5-fluorouracil

Peyman Mohammadzadeh Jahani; Maedeh Jafari; Farhad Nazari Ravari

doi:10.5599/admet.1691

CuFe₂O₄ nanoparticles-based electrochemical sensor for sensitive determination of the anticancer drug 5-fluorouracil

ADMET DMPK. 2023 Mar 15;11(2):201-210. doi: 10.5599/admet.1691. eCollection 2023.

Authors

Peyman Mohammadzadeh Jahani¹, Maedeh Jafari², Farhad Nazari Ravari³

Affiliations

¹ School of Medicine, Bam University of Medical Sciences, Bam, Iran.
² Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
³ Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran.

Abstract

A fast and facile electrochemical sensor for the detection of an important anticancer drug, 5-fluorouracil, is fabricated using CuFe₂O₄ nanoparticles modified screen printed graphite electrode (CuFe₂O₄ NPs/SPGE). The electrochemical activity of the modified electrode was characterized by chronoamperometry, cyclic voltammetry (CV) and differential pulse voltammetry (DPV) and linear sweep voltammetry (LSV) experiments. The CuFe₂O₄ NPs improved the electrochemical properties of the electrodes and enhanced their electroanalytical performance. Electrochemical measurements using differential pulse voltammetry showed a wide linear relationship between 5-fluorouracil concentration and peak height within the range 0.1 to 270.0 μM with a low detection limit (0.03 μM). Further, the sensor was testified with a urine sample and 5-fluorouracil injection sample, and the observed remarkable recovery results replicate its practical applicability.

Keywords: 5-fluorouracil; CuFe2O4 nanoparticles; Modified electrode; SPE; electrochemical sensor; voltammetriy.