Tri-element nanozyme PtCuSe as an ingenious cascade catalytic machine for the amelioration of Parkinson's disease-like symptoms

Hongdang Xu; Xin Ding; Lingrui Li; Qing Li; Zhiye Li; Hongqi Lin

doi:10.3389/fbioe.2023.1208693

Tri-element nanozyme PtCuSe as an ingenious cascade catalytic machine for the amelioration of Parkinson's disease-like symptoms

Front Bioeng Biotechnol. 2023 May 30:11:1208693. doi: 10.3389/fbioe.2023.1208693. eCollection 2023.

Authors

Hongdang Xu¹, Xin Ding², Lingrui Li³, Qing Li³, Zhiye Li³, Hongqi Lin¹

Affiliations

¹ Department of Anesthesiology, Henan Provincial People's Hospital, People's Hospital of Henan University, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan, China.
² Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
³ The Application Center for Precision Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Abstract

Parkinson's disease (PD), as the second most common neurodegenerative disease after Alzheimer's, has become intractable with the increasing aging global population. The exploration of nanomedicine has broadened the opportunities for developing novel neuroprotective therapies. In particular, polymetallic functional nanomaterials have been widely used in the biomedicine field in recent years, exhibiting flexible and diversified functions and controllable properties. In this study, a tri-element nanozyme (PtCuSe nanozyme) has been developed with desirable CAT- and SOD-like activities for the cascade scavenging of reactive oxygen species (ROS). In particular, the nanozyme is suitable for relieving nerve cell damage by removing reactive oxygen species in cells and mitigating the behavioral and pathological symptoms in animal models of Parkinson's disease. Therefore, this ingenious tri-element nanozyme may have potential in the treatment of Parkinson's disease and other neurodegenerative diseases.

Keywords: Parkinson’s disease; PtCuSe; nanozyme; nerve cell damage; reactive oxygen species.

Grants and funding

The authors acknowledge the financial support from the Youth Science Foundation Project of Henan Province (232300421285) and the Joint Project of Medical Science and Technology of Henan Province (LHGJ20220498).