Pituitrin Injection before Hysteroscopic Curettage for Treating Type I Cesarean Scar Pregnancy in Comparison with Uterine Artery Embolization: A Retrospective Study

Juveria Rahman; Yixuan Qiu; Xiong Yuan; Sajjaad H Kassim; Tonghui Ji; Huihua Dai

doi:10.1007/s13224-022-01724-w

Pituitrin Injection before Hysteroscopic Curettage for Treating Type I Cesarean Scar Pregnancy in Comparison with Uterine Artery Embolization: A Retrospective Study

J Obstet Gynaecol India. 2023 Jun;73(3):229-234. doi: 10.1007/s13224-022-01724-w. Epub 2022 Dec 18.

Authors

Juveria Rahman^#¹, Yixuan Qiu^#¹, Xiong Yuan¹, Sajjaad H Kassim², Tonghui Ji¹, Huihua Dai¹

Affiliations

¹ Department of Gynecology, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, 300 Guangzhoulu, Gulou District, Nanjing, Jiangsu 210029 China.
² Nanjing Medical University, Nanjing, Jiangsu 210029 China.

^# Contributed equally.

PMID: 37324364
PMCID: PMC10267048 (available on 2024-06-01)
DOI: 10.1007/s13224-022-01724-w

Abstract

Background: The effectiveness and safety of pituitrin injection coupled with hysteroscopy and suction curettage as treatment for type I cesarean scar pregnancy (CSP) have not been studied enough in the literature, by comparing it to uterine artery embolization (UAE) followed by suction curettage we aim to determine its efficacy.

Materials and methods: Data of 53 patients (the PIT group) with type I CSP treated with pituitrin injection combined with hysteroscopic suction curettage and 137 patients (the UAE group) with type I CSP treated with UAE followed by suction curettage were collected in retrospect. The clinical data were analyzed statistically to compare the efficacy and safety between the two groups.

Results: The PIT group had a shorter duration of postoperative vaginal bleeding, postoperative hospitalization, and overall hospitalization length (P < 0.05). The PIT group had lower overall hospitalization costs and a lower rate of adverse events than the UAE group (P < 0.05). There was no significant difference between the two groups in terms of treatment success rate, the average length of operation, blood loss during the procedure, time when serum β-hCG returned to normal range, and menstrual recovery time after hospital release (P > 0.05).

Conclusion: UAE and pituitrin injection followed by hysteroscopic suction curettage are good choices for type I CSP treatment. However, pituitrin injection with hysteroscopic suction curettage outperforms UAE followed by suction curettage. Thus, pituitrin injection may be an option of high priority for type I CSP.

Keywords: Cesarean scar pregnancy; Hysteroscopy; Pituitrin; Suction curettage; Uterine artery embolization.

© Federation of Obstetric & Gynecological Societies of India 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.