Immunotherapy for ocular melanoma: a bibliometric and visualization analysis from 1991 to 2022

Yao Tan; Yijie Lu; Sheng Chen; Chang Zou; Bo Qin

doi:10.3389/fonc.2023.1161759

Immunotherapy for ocular melanoma: a bibliometric and visualization analysis from 1991 to 2022

Front Oncol. 2023 May 31:13:1161759. doi: 10.3389/fonc.2023.1161759. eCollection 2023.

Authors

Yao Tan¹, Yijie Lu¹, Sheng Chen², Chang Zou^{1

3

4}, Bo Qin^{1

3}

Affiliations

¹ Shenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
² Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Affiliated Hospital of Jinan University, Shenzhen, China.
³ Shenzhen Aier Ophthalmic Technology Institute, Shenzhen, China.
⁴ School of Life and Health Sciences, The Chinese University of Kong Hong, Shenzhen, Guangdong, China.

Abstract

Background: In recent years, new therapeutic options to overcome the mechanisms of tumor immune suppression be effective in the treatment of cutaneous melanoma. These approaches have also been applied in ocular melanoma. The aim of this study is to present the current status and research hotspots of immunotherapy for ocular melanoma from a bibliometric perspective and to explore the field of immunotherapy for malignant ocular melanoma research.

Methods: In this study, the Web of Science Core Collection database (WoSCC) and Pubmed were selected to search the literature related to immunotherapy of ocular melanoma. Using VOSviewer, CiteSpace, the R package "bibliometrix," and the bibliometric online platform through the construction and visualization of bibliometric networks, the country/region, institution, journal, author, and keywords were analyzed to predict the most recent trends in research pertaining to ocular melanoma and immunotherapy.

Results: A total of 401 papers and 144 reviews related to immunotherapy of ocular melanoma were included. The United States is the main driver of research in the field, ranking first in terms of the number of publications, total citations, and H-index. The UNIVERSITY OF TEXAS SYSTEM is the most active institution, contributing the most papers. Jager, Martine is the most prolific author, and Carvajal, Richard is the most frequently cited author. CANCERS is the most published journal in the field and J CLIN ONCOL is the most cited journal. In addition to ocular melanoma and immunotherapy, the most popular keywords were "uveal melanoma" and "targeted therapy". According to keyword co-occurrence and burst analysis, uveal melanoma, immunotherapy, melanoma, metastases, bap1, tebentafusp, bioinformatics, conjunctival melanoma, immune checkpoint inhibitors, ipilimumab, pembrolizumab, and other research topics appear to be at the forefront of this field's research and have the potential to remain a hot research topic in the future.

Conclusion: This is the first bibliometric study in the last 30 years to comprehensively map the knowledge structure and trends in the field of research related to ocular melanoma and immunotherapy. The results comprehensively summarize and identify research frontiers for scholars studying immunotherapy associated with ocular melanoma.

Keywords: CiteSpace; VOSviewer; bibliometric; immunotherapy; ocular melanoma; uveal melanoma.

Publication types

Systematic Review

Grants and funding

This work was supported by the Natural Science Foundation of Guangdong Province, China (2022A1515010742), Shenzhen Science and Technology Innovation Committee, China (JCYJ20180228164300106), and Hunan Provincial Natural Science Foundation of China (2021JJ30045). The Science Research Foundation of Shenzhen Aier Eye Hospital (SZAE2020A02).