Novel amino-Li resin for water-based solid-phase peptide synthesis

Abstract

We report the first application of a novel amino-Li resin to water-based solid-phase peptide synthesis (SPPS) applying the Smoc-protecting group approach. We demonstrated that it is a suitable support for the sustainable water-based alternative to a classical SPPS approach. The resin possesses good swelling properties in aqueous milieu, provides significant coupling sites, and may be applicable to the synthesis of difficult sequences and aggregation-prone peptides.

Keywords: ASPPS; Smoc strategy; solid support; sustainable peptide synthesis; water-based peptide synthesis.