Cracking cancer with engineered skin commensals

Serena Galiè; Luigi Nezi

doi:10.1016/j.chom.2023.05.023

Cracking cancer with engineered skin commensals

Cell Host Microbe. 2023 Jun 14;31(6):919-920. doi: 10.1016/j.chom.2023.05.023.

Authors

Serena Galiè¹, Luigi Nezi²

Affiliations

¹ Department of Experimental Oncology, Istituto Europeo di Oncologia - IRCCS, Milan, Italy.
² Department of Experimental Oncology, Istituto Europeo di Oncologia - IRCCS, Milan, Italy. Electronic address: luigi.nezi@ieo.it.

PMID: 37321175
DOI: 10.1016/j.chom.2023.05.023

Abstract

The use of bacterial colonists as therapy carriers is gaining interest for treating cancer. In a recent publication in Science, the work by Chen et al. proposes the engineering of a commensal bacterium of the human skin microbiota to cross-present tumor antigens to T cells and counteract tumor progression.

MeSH terms

Bacteria / genetics
Humans
Microbiota*
Neoplasms* / therapy
Skin / microbiology
T-Lymphocytes