Fungus-insect interactions beyond bilateral regimes: the importance and strategy to outcompete host ectomicrobiomes by fungal parasites

Abstract

Fungus-insect interactions have long been investigated at the bilateral level to unveil the factors involved in mediating fungal entomopathogenicity and insect antifungal immunity. Emerging evidence has shown that insect cuticles are inhabited by different bacteria that can delay and deter fungal parasite infections. Entomopathogenic fungi (EPF), however, have evolved strategies to combat the colonization resistance mediated by insect ectomicrobiomes by producing antimicrobial peptides or antibiotic compounds. Deprivation of micronutrients may also be employed by EPF to counteract the ectomicrobiome antagonism. Further investigations of insect ectomicrobiome assemblage and fungal factors involved in outcompeting cuticular microbiomes may benefit the development of cost-effective mycoinsecticides while protecting ecologically and economically important insect species.