In this article, we investigate the problem of panoramic image reflection removal to relieve the content ambiguity between the reflection layer and the transmission scene. Although a partial view of the reflection scene is attainable in the panoramic image and provides additional information for reflection removal, it is not trivial to directly apply this for getting rid of undesired reflections due to its misalignment with the reflection-contaminated image. We propose an end-to-end framework to tackle this problem. By resolving misalignment issues with adaptive modules, the high-fidelity recovery of reflection layer and transmission scenes is accomplished. We further propose a new data generation approach that considers the physics-based formation model of mixture images and the in-camera dynamic range clipping to diminish the domain gap between synthetic and real data. Experimental results demonstrate the effectiveness of the proposed method and its applicability for mobile devices and industrial applications.