Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway

Jin Seok Woo; Sun-Hee Hwang; SeungCheon Yang; Kun Hee Lee; Yeon Su Lee; Jeong Won Choi; Jin-Sil Park; JooYeon Jhun; Sung-Hwan Park; Mi-La Cho

doi:10.1186/s12964-023-01141-0

Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway

Cell Commun Signal. 2023 Jun 14;21(1):135. doi: 10.1186/s12964-023-01141-0.

Authors

Jin Seok Woo^#^{1

2}, Sun-Hee Hwang^#^{1

2}, SeungCheon Yang^{1

2}, Kun Hee Lee^{1

2

3}, Yeon Su Lee^{1

2

3}, Jeong Won Choi^{1

2}, Jin-Sil Park^{1

2}, JooYeon Jhun^{1

2

3}, Sung-Hwan Park^{4

5}, Mi-La Cho^{6

7

8

9}

Affiliations

¹ Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea.
² Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea.
³ Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea.
⁴ Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea. rapark@catholic.ac.kr.
⁵ Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea. rapark@catholic.ac.kr.
⁶ Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea. iammila@catholic.ac.kr.
⁷ Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea. iammila@catholic.ac.kr.
⁸ Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea. iammila@catholic.ac.kr.
⁹ Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea. iammila@catholic.ac.kr.

^# Contributed equally.

Abstract

Background: Sjögren's syndrome (SS) is an autoimmune disease characterized by inflammation of the exocrine gland. An imbalance of gut microbiota has been linked to SS. However, the molecular mechanism is unclear. We investigated the effects of Lactobacillus acidophilus (L. acidophilus) and propionate on the development and progression of SS in mouse model.

Methods: We compared the gut microbiomes of young and old mice. We administered L. acidophilus and propionate up to 24 weeks. The saliva flow rate and the histopathology of the salivary glands were investigated, and the effects of propionate on the STIM1-STING signaling pathway were evaluated in vitro.

Results: Lactobacillaceae and Lactobacillus were decreased in aged mice. SS symptoms were ameliorated by L. acidophilus. The abundance of propionate-producing bacterial was increased by L. acidophilus. Propionate ameliorated the development and progression of SS by inhibiting the STIM1-STING signaling pathway.

Conclusions: The findings suggest that Lactobacillus acidophilus and propionate have therapeutic potential for SS. Video Abstract.

Keywords: Lactobacillus acidophilus; Propionate; Sjögren’s syndrome; Stimulation of interferon genes (STING); Stromal interaction moleculae 1 (STIM1).

Publication types

Video-Audio Media
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Inflammation
Lactobacillus acidophilus
Mice
Propionates
Signal Transduction
Sjogren's Syndrome*

Substances

Propionates