Lipid metabolism reprogramming of CD8+ T cell and therapeutic implications in cancer

Runxian Wang; Zhenya Liu; Zhiyao Fan; Hanxiang Zhan

doi:10.1016/j.canlet.2023.216267

Lipid metabolism reprogramming of CD8⁺ T cell and therapeutic implications in cancer

Cancer Lett. 2023 Jul 28:567:216267. doi: 10.1016/j.canlet.2023.216267. Epub 2023 Jun 12.

Authors

Runxian Wang¹, Zhenya Liu¹, Zhiyao Fan¹, Hanxiang Zhan²

Affiliations

¹ Division of Pancreatic Surgery, Department of General Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China.
² Division of Pancreatic Surgery, Department of General Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China. Electronic address: zhanhanxiang@hotmail.com.

PMID: 37315709
DOI: 10.1016/j.canlet.2023.216267

Abstract

Effector, memory and exhaustion are three phenotypes of CD8⁺ T cell. In tumor microenvironment (TME), metabolism dysfunction of the three should take the blame for immune escape. Against background of CD8⁺ T cell in normal development, multiple determinants in TME, including nutrition competition, PD-1 signals and other cancer - CD8⁺ T cell interactions, cause metabolism reprograming, including failure in energy metabolism and other abnormal lipid metabolism. Further, incompatibility among metabolism patterns of three phenotypes results in unresponsiveness of immune checkpoint blockade (ICB). Therefore, combination of ICB and drugs aiming at abnormal lipid metabolism provides promising direction to improve cancer therapy. This review focuses on lipid metabolism of CD8⁺ T cell and aims to provide innovative therapy strategy to cure cancer.

Keywords: Cholesterol; Energy metabolism; Immune checkpoint blockade; Lipid peroxidation; Metabolism regulating drug; Mitochondria.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

CD8-Positive T-Lymphocytes
Energy Metabolism
Humans
Lipid Metabolism*
Neoplasms* / genetics
Neoplasms* / therapy
Nutritional Status
Tumor Microenvironment