SWI/SNF chromatin remodeling complexes as key regulators of CD8+ T cell fate

Lisa Rausch; Axel Kallies

doi:10.1016/j.immuni.2023.05.018

SWI/SNF chromatin remodeling complexes as key regulators of CD8⁺ T cell fate

Immunity. 2023 Jun 13;56(6):1162-1164. doi: 10.1016/j.immuni.2023.05.018.

Authors

Lisa Rausch¹, Axel Kallies²

Affiliations

¹ The Peter Doherty Institute for Infection and Immunity and Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC, Australia.
² The Peter Doherty Institute for Infection and Immunity and Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC, Australia. Electronic address: axel.kallies@unimelb.edu.au.

PMID: 37315531
DOI: 10.1016/j.immuni.2023.05.018

Abstract

CD8⁺ T cell fate is tightly regulated by epigenetic modification. In this issue of Immunity, McDonald et al. and Baxter et al. demonstrate that the chromatin remodeling complexes cBAF and PBAF control proliferation, differentiation, and function of cytotoxic T cells in response to infection as well as cancer.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes*
Cell Differentiation
Chromatin Assembly and Disassembly*
Epigenesis, Genetic
T-Lymphocytes, Cytotoxic