An MYC-Driven Vicious Circuit Is a Targetable Achilles' Heel in Lymphoma

Erica B Wilson; Ulf Klein

doi:10.1158/2643-3230.BCD-23-0053

An MYC-Driven Vicious Circuit Is a Targetable Achilles' Heel in Lymphoma

Blood Cancer Discov. 2023 Jul 5;4(4):248-251. doi: 10.1158/2643-3230.BCD-23-0053.

Authors

Erica B Wilson¹, Ulf Klein¹

Affiliation

¹ Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.

Abstract

In this issue of Blood Cancer Discovery, Nakanishi et al. uncover a critical role for the elevated activity of the translation initiation factor eIF5A in the malignant growth of MYC-driven lymphoma. eIF5A is posttranslationally modified by hypusination through MYC oncoprotein-mediated hyperactivation of the polyamine-hypusine circuit, which may represent a promising therapeutic target because an enzyme of this circuit that is required for hypusinating eIF5A proved to be essential for lymphoma development. See related article by Nakanishi et al., p. 294 (4).

Publication types

Editorial
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Lymphoma*
Neoplasms*
Polyamines
Protein Processing, Post-Translational

Substances

Polyamines
hypusine