Fabrication and biological investigation of a novel star polymer based on magnetic cyclic aromatic polyimide chains

Reza Eivazzadeh-Keihan; Zahra Sadat; Adibeh Mohammadi; Hooman Aghamirza Moghim Aliabadi; Amir Kashtiaray; Ali Maleki; Mohammad Mahdavi

doi:10.1038/s41598-023-36619-x

Fabrication and biological investigation of a novel star polymer based on magnetic cyclic aromatic polyimide chains

Sci Rep. 2023 Jun 13;13(1):9598. doi: 10.1038/s41598-023-36619-x.

Authors

Reza Eivazzadeh-Keihan¹, Zahra Sadat², Adibeh Mohammadi², Hooman Aghamirza Moghim Aliabadi³, Amir Kashtiaray², Ali Maleki⁴, Mohammad Mahdavi⁵

Affiliations

¹ Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran. reza.tab_chemist@yahoo.com.
² Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.
³ Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran.
⁴ Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran. maleki@iust.ac.ir.
⁵ Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. momahdavi@sina.tums.ac.ir.

Abstract

Herein, a novel nanostructure based on cyclic aromatic polyimide with statistical star polymer structure was synthesized via the functionalization of the CuFe₂O₄ MNPs surface. The polymerization process on the functionalized surface of CuFe₂O₄ MNPs was performed with pyromellitic dianhydride and phenylenediamine derivatives. All analytical methods such as Fourier-transform infrared (FT-IR) spectroscopy, thermogravimetric (TG) analysis, X-ray diffraction (XRD) pattern, energy-dispersive X-ray (EDX), field-emission scanning electron microscope (FE-SEM), vibrating-sample magnetometer (VSM) were performed to characterize the structure of CuFe₂O₄@SiO₂-polymer nanomagnetic. The cytotoxicity of CuFe₂O₄@SiO₂-Polymer was investigated for biomedical application by MTT test. The results proved that this nanocmposite was biocompatible with HEK293T healthy cells. Also, the evaluation antibacterial property of CuFe₂O₄@SiO₂-Polymer showed that its MIC in Gram-negative and Gram-positive bacteria were 500-1000 µg/mL, so it had antibacterial activity.