Diffuse optical tomography spatial prior for EEG source localization in human visual cortex

Jiaming Cao; Eli Bulger; Barbara Shinn-Cunningham; Pulkit Grover; Jana M Kainerstorfer

doi:10.1016/j.neuroimage.2023.120210

Diffuse optical tomography spatial prior for EEG source localization in human visual cortex

Neuroimage. 2023 Aug 15:277:120210. doi: 10.1016/j.neuroimage.2023.120210. Epub 2023 Jun 11.

Authors

Jiaming Cao¹, Eli Bulger², Barbara Shinn-Cunningham³, Pulkit Grover⁴, Jana M Kainerstorfer⁵

Affiliations

¹ Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, 15213, Pennsylvania, United States. Electronic address: jiamingc@andrew.cmu.edu.
² Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, 15213, Pennsylvania, United States.
³ Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, 15213, Pennsylvania, United States; Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, 15213, Pennsylvania, United States; Neuroscience Institute, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, 15213, Pennsylvania, United States; Department of Psychology, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, 15213, Pennsylvania, United States.
⁴ Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, 15213, Pennsylvania, United States; Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, 15213, Pennsylvania, United States; Neuroscience Institute, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, 15213, Pennsylvania, United States.
⁵ Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, 15213, Pennsylvania, United States; Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, 15213, Pennsylvania, United States; Neuroscience Institute, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, 15213, Pennsylvania, United States. Electronic address: jkainers@andrew.cmu.edu.

PMID: 37311535
DOI: 10.1016/j.neuroimage.2023.120210

Abstract

Electroencephalography (EEG) and diffuse optical tomography (DOT) are imaging methods which are widely used for neuroimaging. While the temporal resolution of EEG is high, the spatial resolution is typically limited. DOT, on the other hand, has high spatial resolution, but the temporal resolution is inherently limited by the slow hemodynamics it measures. In our previous work, we showed using computer simulations that when using the results of DOT reconstruction as the spatial prior for EEG source reconstruction, high spatio-temporal resolution could be achieved. In this work, we experimentally validate the algorithm by alternatingly flashing two visual stimuli at a speed that is faster than the temporal resolution of DOT. We show that the joint reconstruction using both EEG and DOT clearly resolves the two stimuli temporally, and the spatial confinement is drastically improved in comparison to reconstruction using EEG alone.

Keywords: Diffuse optical tomography; Electroencephalography; Source reconstruction; Spatio-temporal resolution.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Brain Mapping / methods
Computer Simulation
Electroencephalography / methods
Humans
Neuroimaging
Tomography, Optical* / methods
Visual Cortex* / diagnostic imaging