Taxanes directly induce T cell cytotoxic extracellular vesicles to eradicate tumor cells

Ying Xu; Yi Xiao; Zhi-Ming Shao

doi:10.1016/j.ccell.2023.05.012

Taxanes directly induce T cell cytotoxic extracellular vesicles to eradicate tumor cells

Cancer Cell. 2023 Jun 12;41(6):1011-1013. doi: 10.1016/j.ccell.2023.05.012.

Authors

Ying Xu¹, Yi Xiao¹, Zhi-Ming Shao²

Affiliations

¹ Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.
² Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China. Electronic address: zhimingshao@fudan.edu.cn.

PMID: 37311412
DOI: 10.1016/j.ccell.2023.05.012

Abstract

Taxanes are widely used in cancer therapy, yet their mitotic-independent mechanisms in vivo remain enigmatic. Vennin et al. illuminate a mode of action whereby taxanes directly stimulate T cells to release cytotoxic extracellular vesicles to eradicate tumor cells. Taxanes-pre-treated T cells may enhance anti-tumor effects while circumventing systemic toxicity.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Antineoplastic Agents* / pharmacology
Extracellular Vesicles*
Humans
T-Lymphocytes
Taxoids

Substances

Taxoids
Antineoplastic Agents