Platelet-Membrane-Coated Polydopamine Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Repairing Damaged Vessels in Intracerebral Hemorrhage

Canxin Xu; Yuanbo Pan; Hongchi Zhang; Yuhao Sun; Yi Cao; Pengfei Qi; Mingli Li; Ozioma Udochukwu Akakuru; Lulu He; Chen Xiao; Bomin Sun; Liuguan Bian; Juan Li; Aiguo Wu

doi:10.1002/adhm.202300797

Platelet-Membrane-Coated Polydopamine Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Repairing Damaged Vessels in Intracerebral Hemorrhage

Adv Healthc Mater. 2023 Oct;12(26):e2300797. doi: 10.1002/adhm.202300797. Epub 2023 Jun 25.

Authors

Canxin Xu^{1

2}, Yuanbo Pan^{2

3}, Hongchi Zhang¹, Yuhao Sun¹, Yi Cao², Pengfei Qi², Mingli Li², Ozioma Udochukwu Akakuru², Lulu He², Chen Xiao¹, Bomin Sun¹, Liuguan Bian¹, Juan Li², Aiguo Wu²

Affiliations

¹ Department of Neurosurgery, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China.
² Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo, 315201, P. R. China.
³ Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, P. R. China.

PMID: 37310885
DOI: 10.1002/adhm.202300797

Abstract

Intracerebral hemorrhage (ICH) has a high morbidity and mortality rate. Excessive reactive oxygen species (ROS) caused by primary and second brain injury can induce neuron death and inhibit neurological functional recovery after ICH. Therefore, exploring an effective way to noninvasively target hemorrhage sites to scavenge ROS is urgently needed. Inspired by the biological function of platelets to target injury vessel and repair injury blood vessels, platelet-membrane-modified polydopamine (Menp@PLT) nanoparticles are developed with targeting to hemorrhage sites of ICH. Results demonstrate that Menp@PLT nanoparticles can effectively achieve targeting to the location of intracranial hematoma. Furthermore, Menp@PLT with excellent anti-ROS properties can scavenge ROS and improve neuroinflammation microenvironment of ICH. In addition, Menp@PLT may play a role in decreasing hemorrhage volume by repairing injury blood vessels. Combining platelet membrane and anti-ROS nanoparticles for targeting brain hemorrhage sites provide a promising strategy for efficiently treating ICH.

Keywords: BBB permeability; intracerebral hemorrhage; platelet membranes; polydopamine nanoparticles; reactive oxygen species.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cerebral Hemorrhage / drug therapy
Disease Models, Animal
Neuroprotection*
Oxidative Stress* / physiology
Reactive Oxygen Species

Substances

polydopamine
Reactive Oxygen Species