Prognosis to Radiation Unlocked: How Hypoxia Methylome May Hold the Key in HNSCC

Clin Cancer Res. 2023 Aug 15;29(16):2954-2956. doi: 10.1158/1078-0432.CCR-23-1132.

Abstract

Hypoxia in head and neck tumors has proven to be predictive of outcomes. Current hypoxia signatures have failed for patient treatment selection. In a recent study, the authors identified a hypoxia methylation signature as a more robust biomarker in head and neck squamous cell carcinoma and shed light into the mechanism of hypoxia-mediated treatment resistance. See related article by Tawk et al., p. 3051.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Carcinoma, Squamous Cell* / genetics
  • Carcinoma, Squamous Cell* / pathology
  • Carcinoma, Squamous Cell* / radiotherapy
  • Chemoradiotherapy
  • DNA
  • Epigenome
  • Head and Neck Neoplasms* / genetics
  • Head and Neck Neoplasms* / radiotherapy
  • Humans
  • Hypoxia / genetics
  • Neoplasm Recurrence, Local
  • Papillomavirus Infections*
  • Prognosis
  • Squamous Cell Carcinoma of Head and Neck / genetics
  • Squamous Cell Carcinoma of Head and Neck / radiotherapy
  • Tumor Hypoxia / genetics

Substances

  • DNA