A Case Report of Cutaneous Anthrax Diagnosed by Using a Metagenomic Next-Generation Sequencing (mNGS) Approach

Infect Drug Resist. 2023 Jun 7:16:3601-3606. doi: 10.2147/IDR.S411717. eCollection 2023.

Abstract

Anthrax is caused by Bacillus anthracis. Humans are mainly infected through contact with the fur and meat of livestock. The cutaneous form is the most common form. The skin lesions of typical cutaneous anthrax are characterized by shallow ulcers with black crusts, surrounded by small blisters and nonpitting edema of nearby tissues. Metagenomic next-generation sequencing (mNGS) is a new pathogenic detection method which is rapid and unbiased. We reported the first case of cutaneous anthrax diagnosed by mNGS. Ultimately, the man received prompt antibiotic therapy and had a good prognosis. In conclusion, mNGS is proved to be a good method for etiological diagnosis, especially for rare infectious diseases.

Keywords: case report; cutaneous anthrax; etiology diagnosis; mNGS; metagenomic next-generation sequencing.

Publication types

  • Case Reports

Grants and funding

National Natural Science Foundation of China (82070641) Key research and development project of Shaanxi Province (2018ZDXM-SF-037) Project of Shaanxi Provincial Clinical Medical Research Center for Infectious Diseases(2020LCZX-01) Clinical Research Center for Infectious Diseases, the First Affiliated Hospital of Xi'an Jiaotong University (No. XJTU1AF2021CRF-006, 2022-XKCRC-04).